Lesional Psoriatic Epidermis Displays Reduced Neurofibromin Immunoreactivity
نویسندگان
چکیده
منابع مشابه
Fragility of epidermis: acne and post-procedure lesional skin.
'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e.g. stress) and iatrogenic (caused by medical interventions or treatments). ...
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Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they are lipid second messengers produced by sphingolipid metabolism and trigger important cell responses, including protein kinase C-alpha (PKC-alpha) activation and the stimulation of signal transduction pathways wi...
متن کاملExpression of Telomerase Reverse Transcriptase in Psoriatic Lesional Skin
BACKGROUND Little information is known about telomerase expression in the chronic benign hyperproliferative skin disease, psoriasis. Further studies are still required to investigate its usefulness as a biomarker of this skin disorder. AIM To investigate the expression of human telomerase reverse transcriptase (hTERT) in psoriatic lesional skin and its relation to disease severity. METHODS ...
متن کاملImmunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin.
Psoriasis responds favourably to treatment with retinoids but the cellular pathways mediating these effects are poorly understood. Retinoids regulate keratinocyte proliferation and maturation via binding to nuclear retinoic acid receptors (mainly RARalpha and RARgamma) which form heterodimers with the 9-cis-RA receptor, RXRalpha. We have previously shown that mRNA expression of RARalpha and RXR...
متن کاملAltered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis
BACKGROUND Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents. Altered levels of sphingoid bases have been reported in skin conditions that involve dryness and barrier disruption, including atopic dermatitis. OBJECTIVE The purpose of this study was ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1995
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12324333